(Drug Topics) — FDA approved azilsartan medoxomil 40-mg and 80-mg tablets for the treatment of hypertension, either alone or in combination with other antihypertensive agents. A selective AT1 subtype angiotensin II receptor antagonist, azilsartan lowers blood pressure by blocking the action of angiotensin II, a vasopressor hormone that constricts blood vessels.
Efficacy. The antihypertensive efficacy of azilsartan was evaluated in 7 randomized, double-blind trials. Of note, 2 6-week, randomized, double-blind trials compared azilsartan 40 mg and 80 mg to placebo, olmesartan 40 mg, and valsartan 320 mg. Compared to placebo, azilsartan lowered systolic and diastolic blood pressure by up to 15.5 mmHg and 8.6 mmHg, respectively, when measured during clinic visits, and by as much as 14.3 mmHg and 9.4 mmHg, respectively, upon use of 24-hour ambulatory blood pressure monitoring. Most of the antihypertensive effect seen with azilsartan occurred within the first 2 weeks of treatment. When compared to active controls, azilsartan 80 mg daily was found to be statistically superior to the highest FDA-approved doses of olmesartan and valsartan upon both clinic and 24-hour ambulatory blood pressure monitoring.
Safety. Nearly 5,000 patients taking azilsartan (at doses between 20 mg and 80 mg) were evaluated for safety end points during clinical trials. Diarrhea (2%) was the most common adverse effect seen in patients during clinical trials. Other adverse effects (occurring in ≥0.3% of patients and more often than placebo) included: dizziness, cough, asthenia, fatigue, and muscle spasm. As with all approved angiotensin receptor antagonists and other medications that act directly on the renin-angiotensin system, use during pregnancy can result in fetal injury and death and is contraindicated.
Loading ...
Loading ...
Pharma Drugs cause all sorts of problems because they poision ones system, and what happens is that they set up further complications which again need further drugs to offset the problems of the first lot, this is big business for both the MD and of course the Giant Pharma Industry, the whole thing is a Giant Fraud, if people got rid of all fast food Corporations, all GM Food which inhabits the Corporate run Stores,also our WATER which is also full of toxic waste from the above organizations, People need to change their Diets and start taking in proper wholemsome food and preferrably 80% Raw then we would not need the services of the Giant Pharma or its Medical Doctors who havent a clue about how to treat Patients properly but are more concerned about their BANK BALANCES