(Internal Medicine News) — Young adults with hyperuricemia faced a significantly increased risk for later developing hypertension, based on follow-up of more than 4,900 Americans.
This link between hyperuricemia and the later appearance of hypertension did not involve a confounding role by metabolic syndrome. And although the analysis could not establish a causal link between hyperuricemia and hypertension, the results indicated that an elevated serum level of uric acid marks people with an increased risk for later having hypertension, according to Dr. Eswar Krishnan.
In a multivariate analysis that adjusted for baseline differences in subject age, gender, race, serum creatinine clearance, and waist circumferences, people in the highest quartile of serum uric acid level at baseline had a significant, 76%-increased risk for later developing hypertension, compared with the quartile of people with the lowest baseline serum uric acid level, reported Dr. Krishnan, a rheumatologist at Stanford (Calif.) University.
The study used data from the 5,115 people enrolled in the Coronary Artery Risk Development in Young Adults (CARDIA), which entered people aged 18-33 years at four U.S. sites in 1986 and followed them for up to 20 years. Excluding people who at baseline had hypertension or any other component of metabolic syndrome (abdominal obesity, elevated triglycerides, depressed high density lipoprotein cholesterol, elevated fasting glucose) left 4,918 people for the analysis.
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